NEJM 1990: “Chronic Neurologic Manifestations of Lyme Disease”

New England Journal of Medicine (1990)

Eric L. Logigian, M.D., Richard F. Kaplan, Ph.D., and Allen C. Steere, M.D.
N Engl J Med 1990; 323:1438-1444November 22, 1990DOI: 10.1056/NEJM199011223232102

Abstract

BACKGROUND AND METHODS.

Lyme disease, caused by the tick-borne spirochete Borrelia burgdorferi, is associated with a wide variety of neurologic manifestations. To define further the chronic neurologic abnormalities of Lyme disease, we studied 27 patients (age range, 25 to 72 years) with previous signs of Lyme disease, current evidence of immunity toB. burgdorferi, and chronic neurologic symptoms with no other identifiable cause. Eight of the patients had been followed prospectively for 8 to 12 years after the onset of infection.

http://www.nejm.org/doi/full/10.1056/nejm199011223232102

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