Antibiotic retreatment of Lyme disease in patients with persistent symptoms: A biostatistical review of randomized, placebo-controlled, clinical trials

Antibiotic retreatment of Lyme disease in patients with persistent symptoms: A biostatistical review of randomized, placebo-controlled, clinical trials

Allison K. DeLong, Barbara Blossom, Elizabeth Maloney, Steven E. Phillips

Abstract

Introduction
Lyme disease (Lyme borreliosis) is caused by the tick-borne spirochete Borrelia burgdorferi. Long-term persistent illness following antibiotic treatment is not uncommon, particularly when treatment is delayed. Current treatment guidelines for persistent disease primarily rely on findings from four randomized, controlled trials (RCTs), strongly advising against retreatment.

Methods
We performed a biostatistical review of all published RCTs evaluating antibiotic retreatment, focusing on trial design, analysis and conclusions.

<... MORE ...>

Note that Allison DeLong is the statistician appearing in the 2009 IDSA Guidelines review panel and Barbara Maloney is the author of “Challenge to the Recommendation on the Prophylaxis of Lyme Disease” (PDF)

Leave A Comment